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Long R3 IGF-1 has a lower binding affinity for binding proteins such as IGFBP-3, which means it can circulate freely in the bloodstream and exert its anabolic effects on muscle cells without being inhibited by these binding proteins

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In addition to the increased energy expenditure and lipid oxidation, reduced food intake, also described as an effect of oral butyrate supplementation but not an intravenous injection, may contribute to decreased body weight gain induced by butyrate and reduced fat mass (51)

doi: 10.1210/jc.2011-2882 131 ChildCJZimmermannAGScottRSCutlerGBBattelinoTBlumWFet al

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