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Because completion of the full PHES can be time-consuming, the Working Group on HE recommends a simplified battery using two of the following testsnumber connection test-A, number connection test-B, digit symbol test, and the block design testwith CHE defined by impairment in at least two tests [86]

About the review The present Review summarizes evidence from major randomized trials and clinical development programs in the field, drawing on literature identified through database searches including PubMed and focusing on key advances reported through October 2025

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For example, growth hormone-releasing peptides increase levels of IGF-1, a hormone involved in tissue growth and repair