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The outstanding question is long-term cardiovascular safety

10.18203/2319-2003.ijbcp20163153 72 OlagbemideP

By inhibiting the DPP-4 enzyme, Januvia allows GLP-1 and GIP to stay active longer, helping to keep blood sugar steadier throughout the day

The four GLP-1R complexes were prepared for MD simulations with the CHARMM36 force field 56 , employing in-house python htmd 57 and TCL (Tool Command Language) scripts