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This AMFR-S1R-TBK1 linkage provides a direct molecular link between protein quality control and organellar signaling, although its full significance in human metabolic disease remains under investigation

Phospholipid peroxy radicals are relatively unstable and can react with Fe 2+ , resulting in a chain expansion of phospholipid peroxidation, thus triggering ferroptosis signals (31, 32)

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In experimental systems, receptor activation by Cagrilintide has been associated with modulation of neuronal signaling pathways within hindbrain regions involved in metabolic regulation [1]