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In these lawsuits, plaintiffs argue that their symptoms became disabling and were later diagnosed as severe gastroparesis, sometimes described in patient records and testimony as stomach paralysis, or other intestinal motility disorders such as ileus

Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers herceptin resistance in HER2-positive breast cancer

Hopkins D, Lawrence I, Mansell P, et al

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First-in-human study of PC14586, a small molecule structural corrector of Y220C mutant p53, in patients with advanced solid tumors harboring a TP53 Y220C mutation