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The Mayo Clinic recommends strength training for all major muscle groups at least two times per week and notes that You can see significant improvement in your strength with just two or three 20- or 30-minute strength training sessions a week. Mayo Clinic also explains that a single set of 1215 repetitions taken to muscle fatigue can build muscle efficiently for most people. To allow recovery, they recommend resting one full day between training the same muscle groups. On days when energy is lower, shorter sessions or lighter resistance may be more appropriate