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In animal models, both processes are essential for tissue regeneration, providing the theoretical basis for studying them in combination

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Drd2 -floxed mice were created by Shanghai Research Center for Model Organisms

Over longer time periods, namely after 4-OHT induction at E13.5 or E15.5, GFP-negative ECs replace the Bmx-CreERT2 -labeled GFP + cells in submucosal and smaller (distal) mesenteric arteries so that recombined ECs reside only in the larger caliber arteries (Supplementary Fig