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Types of Virtual Consultations Option 1: Asynchronous (Message-Based) How It Works: Complete detailed questionnaire Provider reviews at their convenience Responds via secure messaging within 24-48 hours Back-and-forth messaging for clarification Decision communicated via message Can ask follow-up questions Pros: No scheduled appointment needed Complete at your convenience Often faster overall process Lower cost sometimes Good for straightforward cases Cons: No real-time interaction May need multiple message exchanges Feels less personal Cant ask spontaneous questions Best For: Straightforward weight loss cases People with busy schedules Those comfortable with written communication Patients who dont need extensive discussion Option 2: Live Video Consultation How It Works: Schedule specific appointment time Join video call via platform link Face-to-face virtual discussion (15-30 minutes) Provider reviews your information with you Ask questions in real-time Decision made during or shortly after call Pros: Real-time interaction See providers face and expressions Immediate answers to questions Feels like traditional doctor visit Can show provider relevant information Cons: Must schedule specific time Requires good internet and working camera Some people uncomfortable on video Slightly longer process Best For: People who prefer face-to-face interaction Complex medical situations First-time GLP-1 users with many questions Those wanting more personal connection Option 3: Phone Consultation How It Works: Schedule call time Provider calls you at appointed time Discussion of your health and goals (15-30 minutes) Q&A session Decision communicated Pros: Real-time conversation No video needed (more comfortable for some) Can take call from anywhere Personal interaction Cons: Requires scheduled time No visual component Less common than video or asynchronous Best For: Those without video capability People uncomfortable being on camera Situations where video isnt necessary State laws may dictate which consultation types are permitted in your area

3235 To provide some context, a weight loss of up to about 5% was seen with 4.5 mg of dulaglutide, 7.2% with 2 mg of semaglutide, 10.6% with 2.4 mg of semaglutide in adults with overweight or obesity and T2DM (STEP 2), 35 and 12% with 15 mg of tirzepatide, following treatment periods of 40 to 68 weeks

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7.1 Bayesian perspective: turning evidence asymmetry into communicable probabilities The evidence base for GLP-1RAs in PCOS is asymmetric