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Dark Blue is a UK-based biotech company that is advancing first-in-class small molecule protein degraders targeting MLLT1/3 proteins in acute myeloid leukemia (AML)

We collected conditioned media from stable cancer cells with varying levels of LCRMP-1 and used them to perform in vitro endothelial cell-tube formation assays and in vivo plaque assays (Fig

While these findings provide mechanistic plausibility for L-carnitine's effects on IR, most evidence derives from animal or cellular models, with limited human histological validation or pathway-intervention studies