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Phase-2 trials did report some benefits of ipamorelin in the condition, but the results were not deemed clinically significant within 7-10 days of therapy, leading to discontinuation of trials [9, 10]

It can cross the blood-brain barrier, however, causing unintended side effects in the brain

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Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state