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An overdose of vitamin B12 through diet is hardly possible and also not known, since the required transport protein IF (intrinsic factor) and absorption via the intestinal mucosa are two major barriers

Expert Interview About This Article To increase ferritin levels, try taking an over-the-counter iron supplement if your deficiency is mild

Megadoses of B12 can lead to headaches, nausea, diarrhea, vomiting, and flushing, he says

When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

As interest in this enzyme grew, researchers began developing experimental compounds capable of interacting with NNMT in controlled laboratory environments