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J Hepatol 2022;77:607-18.ArticlePubMed 115

In conclusion, this first report demonstrated a successful desensitization protocol to exenatide in patients with isolated immediate skin reaction and local reactions and indicated the importance of desensitization in patients who do not have alternative therapies

Their primary mechanisms of action include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , which helps control post-meal blood sugar rises Reducing appetite through effects on brain centres that regulate hunger In the UK, GLP-1 receptor agonists are licensed for the treatment of type 2 diabetes mellitus and, in some cases, for weight management in adults with obesity or overweight with weight-related comorbidities