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Let the water trickle down the inside wall of the vial slowly

Our findings are consistent with previous studies showing additional metabolic-cardiovascular-renal benefits of combined GLP-1RA and SGLT2i use in patients with T2D 26 , and suggest a promising role for adding GLP-1RA to SGLT2i therapy in patients with MASLD

Obesity and overweight, which are common in patients with DM2, are a factors that favor the development/progression of CKD through both direct and indirect effects.69 Although the precise mechanisms the association between obesity and CKD are not totally defined it has been proposed that hypertension, glomerular hyperfiltration, hyperglycemia, lipid toxicity, inflammation or the role of adipose tissue and its adipokines are involved.70 Weight reduction by bariatric surgery, pharmacological treatment or dietary measures are associated with a nephroprotective effect,7173 so that weight reduction is a fundamental objective in the nephroprotection of patients with DKD

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