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Tirzepatides long-term data is still accumulating but the profile looks favorable

10.2337/diabetes.55.01.06.db05-0894 Diabetes Metab

The primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which means insulin is released only when blood glucose levels are elevated Suppressing glucagon release from pancreatic alpha cells, thereby reducing hepatic glucose production Slowing gastric emptying , which delays the rate at which food leaves the stomach and enters the small intestine Reducing appetite through central nervous system effects, promoting satiety and decreasing food intake The slowing of gastric emptying is particularly relevant when considering gastrointestinal side effects

However, whether or not polymorphisms in SLC22A4 affect ergothioneine tissue concentrations and/or are linked to disease risk in some individuals remains an open question that should be examined in much larger genetic cohorts (e.g