Evidence increasingly demonstrates that obesity, metabolic syndrome and related comorbidities disrupt reproductive hormone balance, impair spermatogenesis and adversely affect fertility outcomes through complex endocrine, inflammatory, metabolic and epigenetic pathways
Note that the substantial weight loss from either GLP-1s or bariatric surgery is likely to have higher amounts of cost saving and QALY generation beyond the five years modeled in this study, as many of the complications of obesity are expressed later
Diabetes Care 24:489494 Green BD, Irwin N, Duffy NA, Gault VA, OHarte FP, Flatt PR (2006) Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
2009;29(12 Pt 2):33S-42S
Once the injection is complete, lift the pen away from your skin and dispose of it safely