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The reduced reabsorption of Na + from the lumen of the tubule activates the basolateral membrane-associated Na + /Ca 2+ exchanger identified as NCX1 (encoded by the SLC8A1 gene)

The accumulation of amyloid plaques is a pivotal factor associated with subsequent neuronal toxicity in AD pathogenesis, eventually leading to destruction of synaptic structures and severe cognitive deficits (Zhu et al., 2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Strongin RM, Guo Y, Hakuna L, Lowry MA, Escobedo JO

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CagriSema trial dosing only, with no approved label