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Roughly 25 to 35 percent of the weight that GLP-1 patients lose is lean mass, according to a meta-analysis published in March

At week 26, LDL-C was reduced by 19.0% (-36.0% to -1.9%, p=.029) in the tirzepatide 15 mg group compared to placebo while it was reduced by 17.8% (-33.7% to -2.0%, p= 0.028) in the dulaglutide 1.5 mg group compared to placebo though differences between the 2 medications were not seen [60]

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This understanding has led to the development of GLP-1 receptor agonists (such as semaglutide and liraglutide) and dual GIP/GLP-1 receptor agonists (such as tirzepatide) as pharmaceutical treatments