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The Absorption Problem with L-Arginine Here's the research that changed how most clinicians think about this: a landmark pharmacokinetic study found that oral L-arginine is extensively catabolized by arginase enzymes in the intestinal mucosa and by hepatic first-pass metabolism
177 Similar results were reported for patients with and without Hunner lesions for whom multiple therapeutic hydrodistension with 100 cm H 2 O for 5 minutes, over several years, did not significantly change bladder capacity
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