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Regarding dosage , the Phase 2 trial investigated several dose levels administered as a once-weekly subcutaneous injection, ranging from 1 mg up to 12 mg per week , with a gradual escalation schedule

The success of GLP-1 therapy is maximized when combined with healthy lifestyle changes, including a balanced diet and regular physical activity

Some populations, such as adolescents with migraine who suffer from comorbid obesity, may be of interest for further study, as GLP-1 agonists could potentially relieve pain while also addressing obesity [59]

Finally, for the primary endpoint MACE, both SGLT-2 inhibitors and GLP-1RA are similar and both are superior to DPP-4 inhibitors