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With the increasing focus of research on stress in plants that developed in the 1980s, ROS came to be seen as inevitable molecular thugs, a price that had to be paid for aerobic metabolism and that could best be met by careful policing via antioxidant systems

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We prioritized evidence derived from human clinical trials, placing a distinct emphasis on randomized controlled trials (RCTs) and comprehensive systematic reviews published from 2015 onwards, reflecting the most recent and rigorous advancements in the field

Long-term follow-up of healthy people who met whipples triad criteria