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The knockout of PinX1 attenuates the upregulation of cleaved caspase-3 expression, indicating its crucial role in regulating hepatocyte survival and lipid homeostasis [133]

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To demonstrate the effects of SAR425899 on a calculated outcome of -cell functionality, a group of 36 obese patients with type 2 diabetes were given either placebo or a low- or high-dose escalation of SAR425899 over the course of 28 days which demonstrated improvements of 23% (placebo), 163%, and 95% respectively [184]

Following incubation, 10 mL of ice-cold HBSS medium were added to the tubes and pancreata were mechanically digested by vigorous shaking

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