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Thus, it is not surprising that there is a feedback loop where ROS activates autophagy, and activated autophagy triggers the degradation of oxidized proteins and damaged organelles to reduce ROS levels

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The effects of intraperitoneally given berberine at different doses such as 50 mg, 100 mg, or 200 mg per kg before cyclophosphamide administration can decrease CP-mediated hemorrhagic cystitis effectively in dose-dependent behavior