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Cost and Accessibility Insurance coverage is still a challenge for patients seeking these medications for weight loss alone

Set Expectations on Timing: Hair loss typically begins 6-12 weeks after rapid weight loss starts Active shedding improves over 3-6 months once weight stabilizes Complete recovery takes 6-18 months Emphasize Nutrition Support: Providers should offer referrals to dietitians specializing in bariatric/weight loss nutrition who can help maintain adequate protein and micronutrient intake despite appetite suppression

According to Holst this result was especially encouraging

Circ Res (2012) 110(10):132235

The Jastreboff Phase 2 trial randomised 338 adults with body mass index 30 (or 27 with at least one weight-related condition) to retatrutide 1, 4, 8, or 12 mg subcutaneously once weekly, or placebo, for 48 weeks