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What Clinical Guidelines Recommend Current medical guidelines, including recent updates from the UKs National Institute for Health and Care Excellence (NICE) and the British Society for Haematology, explicitly recognize high-dose oral B12 as a safe and cost-effective alternative to injections [12] [3]

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Early studies in Drosophila revealed that MANF deficiency leads to axonal degeneration in dopaminergic neurons, while exogenous supplementation with MANF rescued neuronal survival [151]

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