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Although the magnitude of hydraulic resistance experienced by migrating breast cancer cells in vivo is currently unknown, mathematical modeling indicates that depending on the interstitial fluid viscosity and matrix permeability, the hydraulic resistance within 3D matrices could potentially match or even exceed that observed in microchannels [50, 203]

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By contrast, controlled utilization of lactate, such as lactate post-conditioning, has been demonstrated to exert neuroprotective effects in cerebral IRI (156)

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