IFN- locally increases levels of CXCL9 and CXCL10 in the skin and serum of vitiligo patients, which in turn attracts pathogenic T cells expressing the CXCR3A receptor.18 A predominant lymphocytic infiltrate of CD8+ T cells has been observed in perilesional skin, correlating with disease activity.3 In vitiligo patients, CD8+ T lymphocytes recognize specific melanocyte antigens (MelanA, tyrosinase, gp100, tyrosinase-related proteins 1 and 2, Mart-1)
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Taken together, the available evidence not only demonstrates important physiological and pathological roles for nitrergic co-transmission, but makes clear that these effects are grounded in fundamental ways in both underlying constitutive differences and current state-dependent variations in brain nitrogen load
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showed a positive correlation between dyspepsia and hypothyroidism score [143]
