The non-coenzyme action of thiamine in neurotransmission is further supported by the action of the thiamine analog oxythiamine, whose diphosphorylated derivative (oxyThDP), formed by TPK in vivo , is an antagonist of the coenzyme action of thiamine
(1986) Dec;110(12):1176-9
To effectively intervene in oxidative stress damage within hypoxia-related pathological processes, the core strategy targeting the HIF pathway focuses on regulating the generation and homeostasis of pathological ROS, rather than solely addressing hypoxia adaptation itself
Research indicates that glycine, cysteine, and glutamic acid collectively form the tripeptide structure of glutathione
SUPEROXIDE, HYDROGEN PEROXIDE, AND PEROXYNITRITE GENERATION Despite the fact that superoxide can be generated in extramitochondrial reactions, in most cell types mitochondria appear as the main source of superoxide generation