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Yerba Mat, used since ancient times as a tea, is renowned throughout South America for its rejuvenating, nutritional, and energizing effects, particularly for mental and physical fatigue

Other proposed contributors discussed in the literature include modulation of the dopaminergic and serotonergic systems, growth hormone receptor expression in fibroblasts, and interaction with the nitric oxide system at the level of vasomotor regulation (Sikiric et al., 2018)

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