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Structural analysis together with mutagenesis data revealed mechanisms underlying agonism of different types of GHSR agonists and GHSR-G i coupling

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Pre-treatment of HUVECs with metformin (0.1, 0.5 and 1.0 mmol/L) or liraglutide (3, 10, 30 and 100 nmol/L) was performed 2 h prior to the PA exposure and in 22 h duration

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