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Dysbiosis within the microbiota is strongly associated with changes in the expression of pro-inflammatory cytokines, matrix metalloproteinases (MMPs), and various other biochemical markers.These elements interact through inflammatory responses and oxidative stress pathways, ultimately influencing the stability of fetal membranes

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The charged residues flanking the Syn core, particularly its acidic C-terminal region, may serve as a gatekeeping function 15,68,70