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And it enhances membrane permeability, potentially through interactions with cell surface receptors that recognize arginine-containing compounds

Those with a personal history of suicidal ideation or severe depression should undergo psychiatric evaluation before starting therapy, as rare mood changes have been reported

Long-term users report minimal to no side effects once stabilized on their target dose

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The FDA is not going to accept it works in obese patients as sufficient grounds for a broad AUD label without a corresponding mechanistic story that holds at the receptor level across diverse populations