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If the diagnosis is secondary constipation, efforts should be made to treat the cause (eg, an underlying medical condition or medication side effect), but it may still be helpful for these patients to increase dietary fiber and fluids and to engage in regular physical activity (Rao 2014)

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In the neuronal system, Nox-derived ROS are implicated in blood pressure regulation and hypertension, particularly in response to angiotensin II and aldosterone [75]