It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as well as DNA methylation process, later shown to have significant impacts in various psychiatric diseases
Cohen LH, Vamos E, Heinrichs C, Toppet M, Courtens W, Kumps A, Mardens Y, Carlsson B, Grillner L, Larsson A: Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency
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Cell Metab 31(2):339350 Lee JS, Kang JH, Lee SH et al (2016a) Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC
Abbreviations GST: Glutathione s-transferase GSH: Reduced glutathione GFP: Green fluorescent protein BF: Brightfield PEGDA: Poly(ethylene glycol) diacrylate