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Differential expression analysis was performed using limma-voom, and significance was determined using two-sided statistical testing with multiple-comparison correction (adjusted P value)

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Long-term dosing studies have also been conducted to evaluate tissue tolerance and inflammation markers, suggesting a favorable profile in terms of local joint impact and systemic safety

10 It should be noted that the still popular DPP-4 inhibitor class of agents do not show change in major CV outcomes, either in their individual trials or in meta-analysis

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