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It is important to note that if your body is well-nourished and not deficient in vitamin B12, adding a supplement will not improve the health of your skin, hair, or nails

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In a phase-3 trial including over 2500 overweight and obese individuals (baseline weight 233lb on average), the subjects achieved up to a 20.9% (about 48lb) mean reduction in body weight after 72 weeks at the dose of 15mg/weekly [11]