Alternative approaches to consider before combining medications Before taking the step of adding phentermine to tirzepatide, consider whether any of these evidence-based alternatives might address your plateau or treatment goals without the added risk of combination therapy
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Zinc Supports hair follicle repair, immune balance, and enzyme activity needed for pigmentation
Elevated ROS levels in vitiliginous skin arise from environmental triggers (e.g., UV radiation and chemical exposure), impaired antioxidant enzyme activity, and mitochondrial dysfunction [77]
Classical protease inhibitors such as soybean trypsin inhibitor (SBTI), aprotinin, etc., can enhance absorption, but their clinical translation has been limited due to dose requirements, specificity, degradation, and safety considerations (Renukuntla et al., 2013)