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In TRANSCEND-T2D-1 (type 2 diabetes): nausea 26.5%, diarrhea 22.8%, dysesthesia 4.4%

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Without adequate clearance, histamine accumulates

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its exocrine function involves producing digestive enzymes like trypsin, chymotrypsin (proteases) for proteins, amylase for carbohydrates, and lipase for fats, along with pancreatic juices that aid in the digestion process in the duodenum (Fig

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These cholesterol reductions brought levels comparable to those seen in lean, healthy control mice, suggesting comprehensive metabolic normalization

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