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The importance of ROS on NF-B activation is further supported by studies demonstrating that activation of NF-B by nearly all stimuli can be blocked by antioxidants, such as L-cysteine, N-acetylcysteine (NAC), thiols, green tea polyphenols, and vitamin E [185, 186], although this might be not very specific because antioxidants have multiple targets [187]

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Serotonin, a key neurotransmitter involved in mood regulation and sleep, plays a crucial role in the complex interplay between insomnia and depression

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