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de Magistris, L

Nausea, diarrhea, decreased appetite, and vomiting were the most frequent treatment-emergent AEs in the tirzepatide groups across all SURPASS trials and in the semaglutide 1 mg group in SURPASS-2 (Table 3)

Phase I consist primarily of microsomal enzymes, which are found abundantly in the liver, gastrointestinal tract, lung and kidney, consisting of families and subfamilies of enzymes that are classified based on their amino acid sequence identities or similarities

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Glutathione is a key element of the liver's detoxifying process and also the precursor for glutathione peroxidase, a major free radical scavenging enzyme