Although GLP-1 agents are not first-line therapy for PCOS, they may benefit women with obesity who have not responded adequately to lifestyle interventions and metformin
In individuals with type 2 diabetes, another phase 2 clinical study demonstrated that after 12 weeks of efinopegdutide treatment, although no significant improvement in glycated hemoglobin (HbA1c) levels was observed, the effect on weight loss reached a high of 7.9%, well above the 0.7% weight reduction rate in the placebo group
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Since the neuronal correlates of trial-by-trial variation of self-timing emerged earlier in the cerebellum than in the striatum, the stochastic variation of self-timing might be primarily responsible for neuronal signals in the cerebellum [341]
