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In abiotic stress, GABA signaling elevates cytosolic Ca 2+ , activating GAD through Ca 2+ -calmodulin

Furthermore, NO appears to influence protein kinase B (Akt) signaling though a cGMP/phosphoinositide 3-kinase- (PI3K) dependent pathway [8], which is the primary pathway for up-regulating translation initiation required for muscle protein synthesis (MPS)

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The dietary supplement protandim decreases plasma osteopontin and improves markers of oxidative stress in muscular dystrophy mdx mice