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At 48 weeks on the highest dose (12 mg weekly) (Jastreboff et al., 2023): Nearly two-thirds of participants on the highest dose lost over 20% of their body weight

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Others report no meaningful change, and at least one person who lost 120 pounds on the medication reported that their fibromyalgia symptoms actually intensified rather than improved, which rather pokes a hole in the simple weight loss hypothesis

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Results Prefrontal GABA alterations influence PTSD symptom severity through modulation of cerebral blood flow (cross-sectional clinical study) The study subjects of cross-sectional clinical study consisted of three groups: individuals with PTSD ( N = 78, referred to as the persistent PTSD group), individuals who had recovered from PTSD ( N = 84, referred to as the recovered PTSD group), and healthy individuals without trauma exposure ( N = 86, referred to as the healthy control group)