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Less common but serious side effects include pancreatitis, kidney problems, severe allergic reactions, and low blood sugar

Redox Biol 34 , 101550 (2020)

Its active ingredient, orforglipron, is a non-peptide small molecule synthesized from scratch to mimic GLP-1 receptor activation without being a peptide chain at all

Subsequent increases in the permeability of the intestinal barrier in CKD patients promote the translocation of bacterial products of intestinal origin, such as LPS, uremic toxins, and cytokines, into the systemic circulation, resulting in local and systemic inflammation, as well as oxidative stress associated with CKD (Krukowski et al., 2023

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