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Biochemical analyses ALDH2 enzymatic activity was measured in the liver in order to confirm whether the Aldh2*2 KI homozygous and heterozygous mice have a decreased ALDH2 activity relevant to human ALDH2*2 carriers

One of the most significant genetic factors associated with HT is the human leukocyte antigen - DR gene ( HLA-DR) , particularly the HLA-DR3 , DR4 , and DR5 alleles, which influence antigen presentation and immune response regulation [54, 55]

They act on different hallmarks of aging maintaining telomeres, protecting mitochondria, restoring cellular energy, or countering oxidative stress

The transgenic plants exhibited enhanced tolerance against oxidative stress and increased transcription of antioxidant genes including a GST (Shi et al., 2014)