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Metals are often found to be stored in the vacuole, which is believed to be the primary source of metal requisitioning in root cells (Shabbir et al., 2020)

51 Addressing these adverse effects is crucial for improving patient compliance and therapeutic outcomes

Additionally, the expression of SOD2 genes is regulated by epigenetic factors, and the binding sequences of transcription factors such as transcription factor Sp1, activated protein-2 (AP-2), nuclear factor-B (NF-B), cyclic cAMP-reactive electron binding protein (CREB), and forkhead box class O proteins (FOXOs) are present in its promoter region

Such side effects are usually held in reserve after the body gets accustomed to the drug

For power calculation, SD between 45 and 55 kcal/day and effect sizes between 36 and 84 kcal/day were used based on in-silico trial simulations using existing validated models (24,29,30) using SAR425899 phase 1 trial data as input (13)