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doi: 10.3389/fphar.2026.1752204 Received 22 November 2025 Revised 15 April 2026 Accepted 21 April 2026 Published 15 May 2026 Volume 17 - 2026 Edited by Sathish Kumar Natarajan, University of Nebraska-Lincoln, United States Reviewed by Fabio Vivarelli, University of Bologna, Italy Vijay Radhakrishnan, University of Missouri, United States Updates Copyright 2026 Mahalingam, Kharbanda, Casey and Rasineni

By 2030, more than half of American adults are expected to be classified as obese, with a substantial increase in severe obesity.[56] If unaddressed, this trend will further erode Americas economic potential, placing unprecedented strain on public programs, employer budgets, and national productivity

* Correspondence: Vishwanath Venketaraman, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

When enforcement intensity increases, gaps that were previously tolerated start showing up in FDA correspondence, on Form 483s, or during pre-approval inspections

First, the demographics in this trial are not reflective of the general U.S