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Patients with pre-existing diabetic retinopathy should be monitored closely and may require ophthalmology referral

However, cardiovascular effects warrant careful consideration in the context of tirzepatide therapy

While compounded GLP-1 drugs do serve a purpose, such as serving an individualized patient need, the United States Food and Drug Administration (FDA) has stated its concern with using any non-FDA approved GLP-1 drug

2 Notably, these improvements were not closely correlated with weight loss, suggesting these drugs may have effects on inflammation and pain that go beyond their effect on appetite