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These transporters largely prevent the accumulation of drugs, drug conjugates, nucleosides, and xenobiotics in the brain [12]

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Simultaneously, the AMPK pathway, which may play a significant role in maintaining energy homeostasis, might be indirectly affected by IGF-1 analogs such as IGF-1 LR3

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Upregulation of HSP HSPs are a large family of conserved proteins that act as molecular chaperones and play a key role in protein homeostasis, regulation of apoptosis, and protection from various stresses (such as hypoxia, thermal stress, and oxidative stress) [68]