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Given that retatrutide is currently only available within clinical trials, all participants should have direct access to a trial medical team for any concerns relating to dosing or side effects

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Rare cases of anosmia (loss of smell) have been linked to specific nasal sprays contaminated with harmful ingredients

Peptide therapy is most relevant for patients managing TMJ disorder, myofascial pain syndrome, periodontal disease, chronic oral inflammation, or those seeking to optimize healing around dental implants or surgical procedures

This is corroborated by setmelanotides clinical trials, where participants with monogenic obesity or HO respond more strongly to treatment than general obese participants (NCT02041195, NCT01749137) (75, 77, 79, 87, 9094)