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Along with typical side effects, such as dizziness, drowsiness, nausea, or mild stomach upset, its essential to be aware of the risk of misuse

For example, metformin-treated T2DM patients with elevated levels of Bacteroides fragilis in the gastrointestinal tract, whose metabolite glycoursodeoxycholic acid (GUDCA) is involved in inhibiting FXR signaling (Sun et al., 2018)

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It inhibits NNMT, an enzyme that methylates nicotinamide (a precursor to NAD+)

Several plant extracts have emerged as promising candidates in enhancing GLP-1 activity or mimicking its metabolic benefits